RAPGEF5, Rap guanine nucleotide exchange factor 5

RAPGEF5, Rap guanine nucleotide exchange factor 5

• Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (rap guanine nucleotide exchange factor 5, M-Ras-regulated GEF, M-Ras-regulated Rap GEF, Rap guanine nucleotide exchange factor (GEF) 5, guanine nucleotide exchange factor for Rap1, related to Epac, GFR, MR-GEF, REPAC,)
• NCBI Gene ID: 9771
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8MQ07
  UNIPROT ID#>>Q92565
  UNIPROT ID#>>Q5JPD2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rap guanine nucleotide exchange factor 5 interacts with:

• coiled-coil domain containing 88A
  DDB1 and CUL4 associated factor 15
  DDHD domain containing 2
  mitogen-activated protein kinase 8 interacting protein 2
  muscle RAS oncogene homolog
  placenta associated 9
  RPTOR independent companion of MTOR complex 2
  transmembrane protein 253
  tubulin beta 1 class VI
  VANGL planar cell polarity protein 1
  vir like m6A methyltransferase associated
  WNK lysine deficient protein kinase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.