Studying PROTAC-Mediated Protein Degradation
In this presentation, Promega Senior Research Scientist Jim Vasta explains how NanoBRET® technology can be used to determine cellular permeability and target engagement of PROTAC drug candidates.
NanoBRET® Technology is revolutionizing the study of protein:protein and protein:ligand interactions, allowing in-vivo analysis and quantification of protein dynamics at physiological levels.
The sensitivity of this detection method expands the applications of BRET and allows the development of plate-based assays to screen and quantify drug:target interactions in living cells at scale.