Kinase Selectivity Profiling Systems—Other

V6918-12355MA-panelM
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V6851_Kinase-Selectivity-Profiling-Systems
V6918-12355MA-panelM
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Selectivity Screening of Library Compounds for Effect on a Panel of Kinases

  • Kinase and substrate pairs organized in an easy-to-use 8-tube strip format
  • Simple reaction assembly and automation-friendly protocol
  • Streamlines profiling of hits and leads for potency against families of related kinases

Choose a kinase profiling system

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Catalog number selected: V6918

$ 635.00
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Kinase Selectivity Profiling Systems—Other
Other/CK-1
$ 635.00
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Profile Lead Compounds in Hours, Not Days

The Kinase Selectivity Profiling Systems are ideal for profiling lead-compound kinase inhibitors against a broad panel of kinases to better understand inhibitor activity and obviate any off-target effects. Each system includes kinase and substrate pairs organized in an easy-to-use 8-tube strip format optimized for fast and simple kinase profiling reactions.

The Other/CK-1 and Other-2 Kinase Selectivity Profiling Systems each contain kinase reaction buffer, eight kinases, and eight corresponding substrates and cofactors.

Optimized for Use With ADP-Glo™ Kinase Assay

The Kinase Selectivity Profiling Systems rely on the luminescent ADP-Glo™ Kinase Assay technology to characterize kinase selectivity. The luminescence generated by the ADP-Glo™ Kinase Assay is proportional to ADP concentration and correlates with kinase activity.

Each Kinase Selectivity Profiling System is available with or without ADP-Glo™ Assay reagents.

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Simple, Automation-Friendly Assay, No Time-Consuming Optimization

Simply dilute the stock solutions provided, and you’re ready to go.  Two quick, one-step dilutions provide working stocks of kinases and substrate/cofactor solutions. 

Concentrated kinases and substrates/cofactor stocks are first diluted and then combined with test compound in a 384-well plate. After a 1-hour incubation, the ADP-Glo™ Assay is performed to measure kinase activity.

Kinase profiling method overview 12059ma-w

Assays can be performed manually, or automated on a liquid-handler.

Single-Dose Profiling

Each Kinase Selectivity Profiling System provides enough material to profile up to 20 compounds at a single dose or create a dose response for two compounds against eight kinases at once. 
12060MB-W
Example single-dose inhibitor profiles of eight compounds created using the Kinase Selectivity Profiling System—TK-3. Kinase assays were assembled in the presence of the indicated compounds (1μM final concentration). Kinase activity was quantified using the ADP-Glo™ Kinase Assay. The percent activity of each kinase in the presence of each compound is shown.

Custom Kinase Assay Strips Available

If you need a different combination of kinases than those provided in our catalog, you can design your own custom profiling system using our kinase selector tool.

Protocols

Complete Protocol

Specifications

You are viewing: V6918 Change Configuration

SDS

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Certificate of Analysis

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Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions

AA

See Protocol for detailed storage recommendations.

Specifications

You are viewing: V6919 Change Configuration

What's in the box?

Item Part # Size

Kinase Selectivity Profiling System: Other/CK-1

 V6918 1 × 8 × 50 reactions

ADP-Glo™ Kinase Assay

 V6930 1 × 400 assays

SDS

Search for SDS

Certificate of Analysis

Search by lot number

Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions

See Protocol for detailed storage recommendations.

Patents and Disclaimers

U.S. Pat. Nos. 7,741,067 and 8,361,739.

U.S. Pat. No. 8,183,007 and other patents and patents pending.

U.S. Pat. No. 7,700,310 and other patents and patents pending.

Specifications

You are viewing: V6926 Change Configuration

SDS

Search for SDS

Certificate of Analysis

Search by lot number

Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions

AA

See Protocol for detailed storage recommendations.

Specifications

You are viewing: V6927 Change Configuration

What's in the box?

Item Part # Size

Kinase Selectivity Profiling System: Other-2

 V6926 1 × 8 × 50 reactions

ADP-Glo™ Kinase Assay

 V6930 1 × 400 assays

SDS

Search for SDS

Certificate of Analysis

Search by lot number

Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions

See Protocol for detailed storage recommendations.

Patents and Disclaimers

U.S. Pat. Nos. 7,741,067 and 8,361,739.

U.S. Pat. No. 8,183,007 and other patents and patents pending.

U.S. Pat. No. 7,700,310 and other patents and patents pending.

Resources

Other Resources

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Frequently Used With

ADP-Glo™ Kinase Assay

Universal, luminescent kinase activity assay.

V6930, V9101, V9102, V9103, V9104

GloMax® Discover System

High-performance microplate reader for detecting luminescence, fluorescence and absorbance.

GM3000

GloMax® Navigator System

Dedicated microplate luminometer.

GM2000, GM2010

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