ARFGEF1, ADP ribosylation factor guanine nucleotide exchange factor 1

ARFGEF1, ADP ribosylation factor guanine nucleotide exchange factor 1

• ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]

• Gene Synonyms (ARFGEP1, BIG1, P200, brefeldin A-inhibited guanine nucleotide-exchange protein 1, ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited), p200 ARF guanine nucleotide exchange factor,)
• NCBI Gene ID: 10565
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R7X0
  UNIPROT ID#>>Q9Y6D6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ADP ribosylation factor guanine nucleotide exchange factor 1 interacts with:

• CD244 molecule
  chondroitin sulfate N-acetylgalactosaminyltransferase 1
  dpy-30 histone methyltransferase complex regulatory subunit
  limb development membrane protein 1 like
  lysosomal associated membrane protein 3
  MYC binding protein
  NHL repeat containing 2
  nucleoporin 62
  pleckstrin homology domain containing A4
  PVR related immunoglobulin domain containing
  serine peptidase inhibitor, Kunitz type 2
  SIGLEC family like 1
  TBC1 domain family member 22A
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.