PLEKHA4, pleckstrin homology domain containing A4

PLEKHA4, pleckstrin homology domain containing A4

• This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

• Gene Synonyms (PEPP1, pleckstrin homology domain-containing family A member 4, PH domain-containing family A member 4, phosphoinositol 3-phosphate-binding PH domain protein 1, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4,)
• NCBI Gene ID: 57664
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H4M7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pleckstrin homology domain containing A4 interacts with:

• 3-hydroxyacyl-CoA dehydratase 2
  5'-nucleotidase domain containing 2
  acetoacetyl-CoA synthetase
  acidic residue methyltransferase 1
  actin beta like 2
  actin related protein 8
  activating signal cointegrator 1 complex subunit 2
  acyl-CoA binding domain containing 3
  acyl-CoA synthetase family member 3
  ADP dependent glucokinase
  ADP ribosylation factor like GTPase 8A
  AHNAK nucleoprotein
  alanyl-tRNA synthetase domain containing 1
  aldehyde dehydrogenase 16 family member A1
  ALG2 alpha-1,3/1,6-mannosyltransferase
  anaphase promoting complex subunit 1
  ankyrin repeat domain 27
  apolipoprotein B mRNA editing enzyme catalytic subunit 3F
  apolipoprotein O like
  armadillo repeat containing 6
  asparaginase and isoaspartyl peptidase 1
  ataxin 7 like 3B
  atlastin GTPase 2
  ATP23 metallopeptidase and ATP synthase assembly factor homolog
  ATPase 13A3
  ATPase family AAA domain containing 1
  ATPase family AAA domain containing 3B
  ATPase family AAA domain containing 3C
  ATPase family AAA domain containing 5
  autophagy related 9A
  bolA family member 2B
  BRCA1 associated ATM activator 1
  BRCA1 interacting protein C-terminal helicase 1
  BRI3 binding protein
  calmodulin-lysine N-methyltransferase
  carboxymethylenebutenolidase homolog
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  catechol-O-methyltransferase domain containing 1
  Cbl proto-oncogene like 1
  CCCTC-binding factor like
  CCM2 like scaffold protein
  Cdk5 and Abl enzyme substrate 1
  cell cycle and apoptosis regulator 2
  cell division cycle 73
  centromere protein V
  centrosomal protein 97
  charged multivesicular body protein 6
  chromodomain helicase DNA binding protein 8
  chromosome 1 open reading frame 198
  chromosome 1 open reading frame 35
  chromosome 12 open reading frame 29
  chromosome 18 open reading frame 21
  chromosome 19 open reading frame 47
  chromosome 19 open reading frame 54
  chromosome alignment maintaining phosphoprotein 1
  chromosome transmission fidelity factor 18
  chromosome X open reading frame 56
  cleavage and polyadenylation specific factor 7
  CLPTM1 like
  cms1 ribosomal small subunit homolog
  COBW domain containing 3
  Coenzyme A synthase
  coenzyme Q5, methyltransferase
  coenzyme Q8B
  coiled-coil domain containing 137
  coiled-coil domain containing 85C
  coiled-coil domain containing 86
  coiled-coil-helix-coiled-coil-helix domain containing 6
  collagen beta(1-O)galactosyltransferase 1
  component of oligomeric golgi complex 3
  coronin 7
  CREB regulated transcription coactivator 3
  CWC22 spliceosome associated protein homolog
  cyclin dependent kinase 11A
  cysteinyl-tRNA synthetase 2, mitochondrial
  cytochrome c oxidase assembly factor 8
  cytochrome c oxidase assembly factor COX20
  cytochrome P450 family 4 subfamily X member 1
  cytosolic thiouridylase subunit 1
  cytosolic thiouridylase subunit 2
  dCTP pyrophosphatase 1
  DEAD-box helicase 51
  DEAD-box helicase 54
  DEAD-box helicase 55
  DEAH-box helicase 36
  DEAH-box helicase 40
  decapping mRNA 1B
  decapping mRNA 2
  dedicator of cytokinesis 11
  DENN domain containing 6A
  deoxyhypusine hydroxylase
  dermcidin
  DET1 and DDB1 associated 1
  DExD-box helicase 50
  DExH-box helicase 57
  diaphanous related formin 3
  dihydrouridine synthase 1 like
  divergent protein kinase domain 2A
  DNA polymerase delta interacting protein 3
  DnaJ heat shock protein family (Hsp40) member B8
  DnaJ heat shock protein family (Hsp40) member C21
  dpy-19 like C-mannosyltransferase 3
  dynactin subunit 5
  dynein cytoplasmic 2 heavy chain 1
  dynein light chain roadblock-type 2
  EF-hand domain family member D2
  elaC ribonuclease Z 2
  elongation factor like GTPase 1
  ELOVL fatty acid elongase 1
  endoplasmic reticulum aminopeptidase 2
  engulfment and cell motility 2
  enhancer of mRNA decapping 3
  epidermal growth factor receptor pathway substrate 15 like 1
  epiplakin 1
  epithelial splicing regulatory protein 2
  erythrocyte membrane protein band 4.1 like 5
  establishment of sister chromatid cohesion N-acetyltransferase 2
  eukaryotic elongation factor, selenocysteine-tRNA specific
  eukaryotic translation initiation factor 2 alpha kinase 4
  eukaryotic translation initiation factor 2A
  exocyst complex component 4
  exocyst complex component 8
  exoribonuclease 1
  exosome component 6
  exportin 4
  factor interacting with PAPOLA and CPSF1
  family with sequence similarity 111 member B
  family with sequence similarity 120B
  family with sequence similarity 76 member B
  family with sequence similarity 83 member B
  family with sequence similarity 91 member A1
  family with sequence similarity 98 member B
  family with sequence similarity 98 member C
  FAST kinase domains 5
  fatty acyl-CoA reductase 1
  F-box and leucine rich repeat protein 18
  fidgetin like 1
  flavin adenine dinucleotide synthetase 1
  FLYWCH-type zinc finger 1
  forkhead box K1
  forty-two-three domain containing 1
  fructosamine 3 kinase related protein
  FtsJ RNA 2'-O-methyltransferase 3
  fumarylacetoacetate hydrolase domain containing 1
  G elongation factor mitochondrial 1
  G protein-coupled receptor 89A
  G protein-coupled receptor associated sorting protein 2
  gamma-glutamylcyclotransferase
  gem nuclear organelle associated protein 6
  GEN1 Holliday junction 5' flap endonuclease
  GH3 domain containing
  glutamate rich WD repeat containing 1
  glutamic--pyruvic transaminase 2
  glutamyl-tRNA synthetase 2, mitochondrial
  glutathione S-transferase kappa 1
  glutathione S-transferase theta 2B
  glycerol-3-phosphate acyltransferase 3
  glycerol-3-phosphate acyltransferase 4
  glyoxylate reductase 1 homolog
  golgi phosphoprotein 3
  GrpE like 1, mitochondrial
  GTP binding protein 10
  GTP dependent ribosome recycling factor mitochondrial 2
  GUF1 homolog, GTPase
  H2A.Z variant histone 2
  H3 clustered histone 14
  H6 family homeobox 3
  HDGF like 2
  HEAT repeat containing 6
  heat shock protein family A (Hsp70) member 12A
  HECT domain E3 ubiquitin protein ligase 3
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C like 2
  heterogeneous nuclear ribonucleoprotein L like
  heterogeneous nuclear ribonucleoprotein U like 2
  histocompatibility minor 13
  HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
  hydroxysteroid dehydrogenase like 1
  hydroxysteroid dehydrogenase like 2
  importin 4
  inositol 1,4,5-trisphosphate receptor interacting protein
  integrator complex subunit 14
  integrator complex subunit 3
  integrator complex subunit 5
  interferon regulatory factor 2 binding protein 2
  intraflagellar transport 74
  inverted formin 2
  iron-sulfur cluster assembly 2
  iron-sulfur cluster assembly factor IBA57
  isoamyl acetate hydrolyzing esterase 1 (putative)
  isochorismatase domain containing 2
  itchy E3 ubiquitin protein ligase
  junction mediating and regulatory protein, p53 cofactor
  Jupiter microtubule associated homolog 2
  katanin catalytic subunit A1 like 1
  kelch like family member 12
  kelch like family member 15
  KIAA1671
  KIAA2013
  kinesin family member 18B
  kinesin family member 7
  kinesin light chain 2
  kinesin light chain 4
  kinetochore localized astrin (SPAG5) binding protein
  KRI1 homolog
  KTI12 chromatin associated homolog
  L-2-hydroxyglutarate dehydrogenase
  La ribonucleoprotein 4
  lamin B2
  LAS1 like ribosome biogenesis factor
  leucine rich repeats and WD repeat domain containing 1
  leukocyte receptor cluster member 8
  lin-7 homolog B, crumbs cell polarity complex component
  lipase maturation factor 2
  lipid droplet associated hydrolase
  LMBR1 domain containing 2
  lon peptidase 2, peroxisomal
  LSM12 homolog
  lysocardiolipin acyltransferase 1
  lysophosphatidylcholine acyltransferase 1
  lysophospholipase like 1
  MAPK regulated corepressor interacting protein 1
  matrix AAA peptidase interacting protein 1
  meiotic double-stranded break formation protein 4
  membrane bound O-acyltransferase domain containing 2
  membrane bound O-acyltransferase domain containing 7
  metadherin
  metaxin 3
  methylcrotonoyl-CoA carboxylase 2
  methylthioribose-1-phosphate isomerase 1
  methyltransferase like 15
  methyltransferase like 7B
  microtubule interacting and trafficking domain containing 1
  minichromosome maintenance complex binding protein
  mitochondrial calcium uniporter
  mitochondrial contact site and cristae organizing system subunit 13
  mitochondrial E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein L1
  mitochondrial ribosomal protein L11
  mitochondrial ribosomal protein L14
  mitochondrial ribosomal protein L17
  mitochondrial ribosomal protein L21
  mitochondrial ribosomal protein L24
  mitochondrial ribosomal protein L38
  mitochondrial ribosomal protein L41
  mitochondrial ribosomal protein L43
  mitochondrial ribosomal protein L44
  mitochondrial ribosomal protein L53
  mitochondrial ribosomal protein L9
  mitochondrial ribosomal protein S14
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S25
  mitochondrial ribosomal protein S34
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S5
  mitochondrial ribosomal protein S6
  mitochondrial ribosomal protein S9
  mitochondrial transcription termination factor 4
  MMS19 homolog, cytosolic iron-sulfur assembly component
  MORC family CW-type zinc finger 4
  motile sperm domain containing 2
  MTOR associated protein, LST8 homolog
  multivesicular body subunit 12A
  myosin heavy chain 14
  myosin light chain 12B
  myosin light chain 6B
  myosin XIX
  myosin XVIIIA
  MYST/Esa1 associated factor 6
  NADH:ubiquinone oxidoreductase core subunit S7
  N-alpha-acetyltransferase 11, NatA catalytic subunit
  N-alpha-acetyltransferase 15, NatA auxiliary subunit
  N-alpha-acetyltransferase 16, NatA auxiliary subunit
  N-alpha-acetyltransferase 35, NatC auxiliary subunit
  NEDD1 gamma-tubulin ring complex targeting factor
  neuralized E3 ubiquitin protein ligase 4
  NFKB activating protein like
  NIMA related kinase 7
  NIMA related kinase 9
  nitric oxide associated 1
  NODAL modulator 2
  non-SMC condensin I complex subunit G
  NOP2/Sun RNA methyltransferase 6
  NOP9 nucleolar protein
  nuclear receptor coactivator 5
  nuclear speckle splicing regulatory protein 1
  nuclear transcription factor, X-box binding like 1
  nucleolar complex associated 4 homolog
  nucleolar protein 10
  nucleolar protein 6
  nucleolar protein 9
  nucleolar protein interacting with the FHA domain of MKI67
  nucleoporin 35
  nucleoporin 37
  nucleoporin 85
  nucleoredoxin
  nucleoside-triphosphatase, cancer-related
  NUF2 component of NDC80 kinetochore complex
  occludin
  OCIA domain containing 2
  OTU deubiquitinase with linear linkage specificity
  oxidoreductase NAD binding domain containing 1
  oxysterol binding protein like 8
  PAT1 homolog 1, processing body mRNA decay factor
  penta-EF-hand domain containing 1
  peptidase M20 domain containing 2
  peptidylprolyl isomerase like 4
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  PHD finger protein 5A
  PHD finger protein 6
  phosphatidylinositol glycan anchor biosynthesis class S
  phosphoglucomutase 2 like 1
  phosphoglycolate phosphatase
  phosphoribosyl pyrophosphate synthetase 1 like 1
  pleckstrin homology domain containing A1
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing A7
  poly(A) binding protein cytoplasmic 1 like
  poly(A) polymerase gamma
  polyribonucleotide nucleotidyltransferase 1
  POM121 transmembrane nucleoporin C
  potassium channel tetramerization domain containing 12
  potassium channel tetramerization domain containing 15
  POTE ankyrin domain family member F
  programmed cell death 2 like
  proline rich coiled-coil 2B
  prolyl 3-hydroxylase 1
  proteasome 20S subunit alpha 8
  protein tyrosine phosphatase mitochondrial 1
  pseudouridine synthase 1
  pyrroline-5-carboxylate reductase 3
  queuine tRNA-ribosyltransferase accessory subunit 2
  RAB, member of RAS oncogene family like 3
  RAB1B, member RAS oncogene family
  RAB34, member RAS oncogene family
  RAD50 interactor 1
  RALY RNA binding protein like
  RANBP2 like and GRIP domain containing 3
  RAP2C, member of RAS oncogene family
  ras homolog family member T2
  Ras related GTP binding C
  RBMX like 1
  RCC1 like
  RecQ mediated genome instability 2
  regulation of nuclear pre-mRNA domain containing 1B
  required for meiotic nuclear division 5 homolog A
  reticulophagy regulator family member 3
  retinol dehydrogenase 13
  RFT1 homolog
  Rho GTPase activating protein 39
  ribonuclease P/MRP subunit p25 like
  ribosomal oxygenase 1
  ribosomal protein L10 like
  ribosomal protein L7 like 1
  ribosomal protein S19 binding protein 1
  ribosomal protein SA pseudogene 58
  ribosomal RNA processing 36
  RIC8 guanine nucleotide exchange factor A
  RIO kinase 1
  RNA binding fox-1 homolog 3
  RNA binding motif protein 12B
  RNA binding motif protein 15
  RNA binding motif protein 17
  RNA binding motif protein 25
  RNA binding motif protein 33
  RNA binding motif protein 42
  RNA binding motif protein 45
  RNA binding motif protein 4B
  RNA guanine-7 methyltransferase activating subunit
  RNA pseudouridine synthase D3
  rogdi atypical leucine zipper
  RPTOR independent companion of MTOR complex 2
  RUS family member 1
  SAFB like transcription modulator
  salvador family WW domain containing protein 1
  SAS-6 centriolar assembly protein
  schlafen family member 11
  scinderin
  sec1 family domain containing 2
  SEH1 like nucleoporin
  selenoprotein O
  serine racemase
  serine/threonine kinase 33
  serine/threonine kinase 35
  sestrin 2
  SH3KBP1 binding protein 1
  shootin 1
  sideroflexin 1
  sideroflexin 2
  sideroflexin 4
  SIN3-HDAC complex associated factor
  small ArfGAP 1
  solute carrier family 16 member 10
  solute carrier family 25 member 19
  solute carrier family 25 member 21
  solute carrier family 35 member E1
  sorting nexin 6
  sosondowah ankyrin repeat domain family member C
  SPC24 component of NDC80 kinetochore complex
  spermatogenesis associated 5
  sphingolipid transporter 1 (putative)
  spindle and kinetochore associated complex subunit 3
  spindlin interactor and repressor of chromatin binding
  splicing factor 3b subunit 5
  SRA stem-loop interacting RNA binding protein
  SRP receptor subunit beta
  sterile alpha motif domain containing 1
  striatin interacting protein 1
  structural maintenance of chromosomes 6
  STT3 oligosaccharyltransferase complex catalytic subunit B
  sulfide quinone oxidoreductase
  synaptosome associated protein 47
  TAM41 mitochondrial translocator assembly and maintenance homolog
  target of EGR1, exonuclease
  TATA-box binding protein like 2
  taxilin alpha
  TBC1 domain family member 15
  TBL1X receptor 1
  TELO2 interacting protein 2
  TEPSIN adaptor related protein complex 4 accessory protein
  terminal uridylyl transferase 7
  tetratricopeptide repeat domain 13
  tetratricopeptide repeat domain 21B
  tetratricopeptide repeat domain 7B
  tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
  THADA armadillo repeat containing
  thiamine triphosphatase
  thioredoxin domain containing 5
  thioredoxin related transmembrane protein 1
  THO complex 6
  threonyl-tRNA synthetase 2, mitochondrial
  threonyl-tRNA synthetase 3
  torsin 1A interacting protein 2
  TP53 regulating kinase
  TraB domain containing
  trafficking protein particle complex 1
  trafficking protein particle complex 5
  transducin beta like 1 Y-linked
  trans-L-3-hydroxyproline dehydratase
  translocase of inner mitochondrial membrane 23 homolog B
  translocase of inner mitochondrial membrane 29
  translocase of inner mitochondrial membrane 50
  transmembrane O-mannosyltransferase targeting cadherins 3
  transmembrane protein 109
  transmembrane protein 126A
  transmembrane protein 168
  transmembrane protein 199
  transmembrane protein 201
  transmembrane protein 223
  transmembrane protein 263
  transmembrane protein 41A
  transmembrane protein 43
  transmembrane protein with metallophosphoesterase domain
  tripartite motif containing 4
  tripartite motif containing 65
  tripartite motif containing 9
  tRNA methyltransferase 1 like
  tRNA methyltransferase 2 homolog B
  tRNA methyltransferase 44 homolog
  tRNA splicing endonuclease subunit 2
  tRNA splicing endonuclease subunit 34
  tRNA-yW synthesizing protein 3 homolog
  TruB pseudouridine synthase family member 1
  TSR3 ribosome maturation factor
  tubulin alpha 1c
  tubulin alpha 4b
  tubulin beta 2B class IIb
  tubulin beta 6 class V
  tubulin beta class I
  tubulin gamma complex associated protein 5
  tubulin gamma complex associated protein 6
  tudor domain containing 3
  UBA domain containing 2
  ubiquitin conjugating enzyme E2 N like (gene/pseudogene)
  ubiquitin conjugating enzyme E2 O
  ubiquitin like 5
  ubiquitin protein ligase E3D
  ubiquitin specific peptidase 27 X-linked
  ubiquitin specific peptidase 30
  ubiquitin specific peptidase 54
  unk zinc finger
  UPF3B regulator of nonsense mediated mRNA decay
  uracil phosphoribosyltransferase homolog
  UTP15 small subunit processome component
  UTP4 small subunit processome component
  VPS16 core subunit of CORVET and HOPS complexes
  VPS33A core subunit of CORVET and HOPS complexes
  VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
  VPS37B subunit of ESCRT-I
  WASH complex subunit 2A
  WD repeat domain 26
  WD repeat domain 36
  WD repeat domain 61
  WD repeat domain 62
  WD repeat domain 75
  WD repeat domain 76
  WD repeat domain 77
  WD repeat domain 82
  WD repeat domain 89
  WIZ zinc finger
  WNK lysine deficient protein kinase 1
  Yip1 domain family member 5
  Yip1 interacting factor homolog B, membrane trafficking protein
  yrdC N6-threonylcarbamoyltransferase domain containing
  YTH domain containing 1
  YTH domain containing 2
  ZFP42 zinc finger protein
  ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
  zinc binding alcohol dehydrogenase domain containing 2
  zinc finger and BTB domain containing 10
  zinc finger and SCAN domain containing 18
  zinc finger C3H1-type containing
  zinc finger CCCH-type containing 14
  zinc finger CCCH-type containing 18
  zinc finger protein 326
  zinc finger protein 362
  zinc finger protein 512
  zinc finger protein 574
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 622
  zinc finger protein 703
  zinc finger protein 740
  zinc finger protein 768
  zinc finger protein 787
  zinc finger protein 829

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.