WDR45, WD repeat domain 45

WDR45, WD repeat domain 45

• This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (WD repeat domain phosphoinositide-interacting protein 4, WD repeat domain, X-linked 1, WD repeat-containing protein 45, WD45 repeat protein interacting with phosphoinositides 4, neurodegeneration with brain iron accumulation 4, neurodegeneration with brain iron accumulation 5, JM5, NBIA4, NBIA5, WDRX1, WIPI-4, WIPI4,)
• NCBI Gene ID: 11152
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y484
  UNIPROT ID#>>A0A024QYX1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

WD repeat domain 45 interacts with:

• autophagy related 2A
  autophagy related 2A
  autophagy related 2B
  centrosomal protein 89
  dual specificity phosphatase 26
  histone deacetylase 11
  LIM homeobox 6
  pleckstrin homology domain containing A4
  POC1 centriolar protein A
  X antigen family member 1A

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