ARHGAP26, Rho GTPase activating protein 26

ARHGAP26, Rho GTPase activating protein 26

• Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

• Gene Synonyms (GRAF, GRAF1, OPHN1L, OPHN1L1, rho GTPase-activating protein 26, GTPase regulator associated with focal adhesion kinase pp125(FAK), oligophrenin-1-like protein,)
• NCBI Gene ID: 23092
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UNA1
  UNIPROT ID#>>A0A0S2Z536
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho GTPase activating protein 26 interacts with:

• C2 calcium dependent domain containing 2
  junctophilin 1
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1
  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
  NHL repeat containing 2
  protein kinase N3
  RAB11 family interacting protein 5
  Rho GTPase activating protein 10
  Rho GTPase activating protein 42
  SMAD specific E3 ubiquitin protein ligase 1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.