SMURF1, SMAD specific E3 ubiquitin protein ligase 1

SMURF1, SMAD specific E3 ubiquitin protein ligase 1

• This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

• Gene Synonyms (E3 ubiquitin-protein ligase SMURF1, E3 ubiquitin ligase SMURF1, HECT-type E3 ubiquitin transferase SMURF1, Smad ubiquitination regulatory factor 1, Smad-specific E3 ubiquitin ligase 1, hSMURF1,)
• NCBI Gene ID: 57154
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HCE7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SMAD specific E3 ubiquitin protein ligase 1 interacts with:

• activating signal cointegrator 1 complex subunit 2
  adaptor-related protein complex 2, beta 1 subunit
  ADP ribosylation factor like GTPase 14
  ADP-ribosylation factor-like 4D
  anaphase-promoting complex subunit 5
  ankyrin repeat and sterile alpha motif domain containing 4B
  ankyrin repeat domain 13A
  ankyrin repeat domain 13D
  ankyrin repeat domain 50
  apoptosis, caspase activation inhibitor
  calcium binding and coiled-coil domain 1
  carboxymethylenebutenolidase homolog
  CCM2 scaffold protein
  cell division cycle 40
  coiled-coil domain containing 88C
  CUE domain containing 1
  cullin 5
  CXXC finger 1 (PHD domain)
  cyclin-dependent kinase-like 1 (CDC2-related kinase)
  DEAD-box helicase 54
  E2F transcription factor 7
  elongation factor 1 homolog
  elongator acetyltransferase complex subunit 3
  F-box and leucine rich repeat protein 15
  F-box protein 24
  F-box protein 3
  F-box protein 30
  FCH domain only 1
  GAR1 ribonucleoprotein
  guanine nucleotide binding protein (G protein), gamma 11
  heterogeneous nuclear ribonucleoprotein A3
  inflammation and lipid regulator with UBA-like and NBR1-like domains
  inhibitor of growth family, member 2
  interleukin-1 receptor-associated kinase 2
  LON peptidase N-terminal domain and ring finger 3
  LON peptidase N-terminal domain and ring finger 3
  MINDY lysine 48 deubiquitinase 3
  mitochondrial antiviral signaling protein
  N(alpha)-acetyltransferase 20, NatB catalytic subunit
  N-alpha-acetyltransferase 16, NatA auxiliary subunit
  Nedd4 family interacting protein 1
  occludin
  OTU deubiquitinase 1
  oxysterol binding protein-like 3
  PAK1 interacting protein 1
  PWP1 homolog, endonuclein
  ral guanine nucleotide dissociation stimulator-like 3
  RASD family, member 2
  receptor (TNFRSF)-interacting serine-threonine kinase 2
  Rho GTPase activating protein 15
  Rho GTPase activating protein 31
  Rho guanine nucleotide exchange factor (GEF) 11
  rhophilin Rho GTPase binding protein 2
  Rho-related BTB domain containing 1
  ribosomal protein S27A
  ring finger protein 141
  RIO kinase 1
  RNA binding motif protein 17
  SCY1 like pseudokinase 1
  serine and arginine-rich splicing factor 4
  serine/threonine kinase 35
  SET domain containing 7, histone lysine methyltransferase
  SLAIN motif family member 2
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  splicing factor 3a, subunit 1
  SUMO peptidase family member, NEDD8 specific
  target of myb1 like 2 membrane trafficking protein
  testis-specific serine kinase 5
  TNFAIP3 interacting protein 2
  translocase of inner mitochondrial membrane 50
  tribbles pseudokinase 3
  tripartite motif-containing 35
  tubulin beta class I
  ubiquitin specific peptidase 45
  ubiquitin specific petidase 45
  UBX domain protein 6
  unk like zinc finger
  WD repeat domain 61
  WD repeat domain 61
  WD repeat domain 77
  zinc finger and BTB domain containing 8b
  zinc finger and BTB domain containing 8B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.