LATS2, large tumor suppressor kinase 2

LATS2, large tumor suppressor kinase 2

• This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

• Gene Synonyms (serine/threonine-protein kinase LATS2, LATS (large tumor suppressor, Drosophila) homolog 2, LATS, large tumor suppressor, homolog 2, kinase phosphorylated during mitosis protein, large tumor suppressor homolog 2, serine/threonine kinase KPM, serine/threonine-protein kinase kpm, warts-like kinase, KPM,)
• NCBI Gene ID: 26524
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NRM7
  UNIPROT ID#>>A0A024RDM3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

large tumor suppressor kinase 2 interacts with:

• ajuba LIM protein
  anaphase promoting complex subunit 1
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 5
  anaphase promoting complex subunit 7
  angiomotin
  angiomotin like 1
  angiomotin like 2
  APC membrane recruitment protein 1
  carboxypeptidase vitellogenic like
  cell division cycle 26
  centrobin, centriole duplication and spindle assembly protein
  centromere protein J
  centrosomal protein 128
  centrosomal protein 192
  centrosomal protein 295
  centrosomal protein 72
  centrosomal protein 85
  centrosomal protein 89
  centrosome and spindle pole associated protein 1
  cingulin
  coiled-coil domain containing 77
  coiled-coil domain containing 85C
  coiled-coil domain containing 88C
  DND microRNA-mediated repression inhibitor 1
  eukaryotic translation initiation factor 4E nuclear import factor 1
  F-box and leucine rich repeat protein 16
  fizzy and cell division cycle 20 related 1
  GLIS family zinc finger 1
  GLIS family zinc finger 2
  GRB10 interacting GYF protein 1
  junctional cadherin 5 associated
  KIAA1549
  KIAA1671
  kinesin family member 23
  large tumor suppressor kinase 2
  leucine zipper tumor suppressor 2
  ligand of numb-protein X 2
  lin-7 homolog C, crumbs cell polarity complex component
  membrane palmitoylated protein 5
  MIA SH3 domain ER export factor 3
  mirror-image polydactyly 1
  MOB kinase activator 1A
  MOB kinase activator 1B
  MOB kinase activator 3A
  MOB kinase activator 3B
  MOB kinase activator 3C
  NCK associated protein 5 like
  ninein
  NME/NM23 family member 7
  par-3 family cell polarity regulator
  PDZ domain containing 11
  pleckstrin homology and RhoGEF domain containing G1
  pleckstrin homology domain containing A1
  pleckstrin homology domain containing A5
  pleckstrin homology domain containing A7
  pleckstrin homology like domain family B member 2
  Rap associating with DIL domain
  RNA binding motif protein 15
  salvador family WW domain containing protein 1
  signal induced proliferation associated 1 like 2
  spindle and centriole associated protein 1
  SSX family member 2 interacting protein
  syntaxin binding protein 4
  TANK binding kinase 1
  trichoplein keratin filament binding
  tubulin beta 6 class V
  ubiquitin specific peptidase 54
  WT1 interacting protein
  WW and C2 domain containing 2
  WWC family member 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.