UBN1, ubinuclein 1

UBN1, ubinuclein 1

• Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]

• Gene Synonyms (ubinuclein-1, HIRA-binding protein, ubiquitously expressed nuclear protein, VT, VT4,)
• NCBI Gene ID: 29855
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NPG3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubinuclein 1 interacts with:

• anti-silencing function 1B histone chaperone
  B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  BRF2 RNA polymerase III transcription initiation factor subunit
  microtubule associated serine/threonine kinase like
  SET nuclear oncogene
  WD repeat domain 36
  zinc finger protein 606

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.