NGF, nerve growth factor

NGF, nerve growth factor

• This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (Beta-NGF, HSAN5, NGFB, beta-nerve growth factor, nerve growth factor (beta polypeptide), nerve growth factor, beta subunit, pro-nerve growth factor long,)
• NCBI Gene ID: 4803
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P01138
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nerve growth factor interacts with:

• nerve growth factor
  nerve growth factor receptor
  neurotrophic receptor tyrosine kinase 1
  plasminogen
  sortilin 1
  sortilin related VPS10 domain containing receptor 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.