PF4, platelet factor 4

PF4, platelet factor 4

• This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

• Gene Synonyms (platelet factor 4, C-X-C motif chemokine 4, chemokine (C-X-C motif) ligand 4, iroplact, oncostatin-A, CXCL4, PF-4, SCYB4,)
• NCBI Gene ID: 5196
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P02776
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

platelet factor 4 interacts with:

• C-C motif chemokine ligand 5
  C-X-C motif chemokine ligand 12
  platelet factor 4
  protein C, inactivator of coagulation factors Va and VIIIa
  serglycin
  syndecan 2
  thrombomodulin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.