PROC, protein C, inactivator of coagulation factors Va and VIIIa

PROC, protein C, inactivator of coagulation factors Va and VIIIa

• This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

• Gene Synonyms (vitamin K-dependent protein C, Protein C-Nagoya, activated protein C, anticoagulant protein C, autoprothrombin IIA, blood coagulation factor XIV, prepro-protein C, type I protein C, APC, PC, PROC1, THPH3, THPH4,)
• NCBI Gene ID: 5624
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P04070
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein C, inactivator of coagulation factors Va and VIIIa interacts with:

• cysteine rich tail 1
  EPH receptor A6
  neuropeptide B
  peptide deformylase, mitochondrial
  protein C receptor
  protein C, inactivator of coagulation factors Va and VIIIa
  protein S
  thrombomodulin
  thymidine kinase 1
  ubiquinol-cytochrome c reductase hinge protein
  Wnt family member 5A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.