MARCHF5, membrane associated ring-CH-type finger 5

MARCHF5, membrane associated ring-CH-type finger 5

• MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase MARCHF5, E3 ubiquitin-protein ligase MARCH5, RING-type E3 ubiquitin transferase MARCH5, RING-type E3 ubiquitin transferase MARCHF5, membrane associated ring finger 5, membrane-associated RING finger protein 5, membrane-associated RING-CH protein V, membrane-associated ring finger (C3HC4) 5, mitochondrial ubiquitin ligase, ring finger protein 153, MARCH-V, MARCH5, MITOL, RNF153,)
• NCBI Gene ID: 54708
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NX47
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

membrane associated ring-CH-type finger 5 interacts with:

• AKT interacting protein
  ankyrin repeat and sterile alpha motif domain containing 6
  fetal and adult testis expressed 1
  FUN14 domain containing 1
  glutathione peroxidase 8 (putative)
  GRAM domain containing 2B
  hydroxysteroid 17-beta dehydrogenase 13
  mannosidase beta like
  membrane associated ring-CH-type finger 5
  MIA SH3 domain ER export factor 3
  mitochondrial antiviral signaling protein
  mitofusin 1
  outer dense fiber of sperm tails 4
  pleckstrin homology domain containing A4
  protein tyrosine phosphatase non-receptor type 5
  reticulon 4 interacting protein 1
  secretion associated Ras related GTPase 1A
  solute carrier family 25 member 26
  solute carrier family 25 member 38
  solute carrier family 25 member 46
  stathmin 4
  transmembrane protein 139
  transmembrane protein 14B
  ubiquitin conjugating enzyme E2 W
  unk zinc finger

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.