RNF111, ring finger protein 111

RNF111, ring finger protein 111

• The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

• Gene Synonyms (E3 ubiquitin-protein ligase Arkadia, Arkadia, RING-type E3 ubiquitin transferase Arkadia, ARK, hRNF111,)
• NCBI Gene ID: 54778
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R5T5
  UNIPROT ID#>>Q6ZNA4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 111 interacts with:

• cilia and flagella associated protein 298
  defective in cullin neddylation 1 domain containing 5
  deltex E3 ubiquitin ligase 3L
  EDAR associated death domain
  epithelial splicing regulatory protein 1
  epithelial splicing regulatory protein 2
  keratin associated protein 1-1
  late cornified envelope 4A
  leucine rich repeat and sterile alpha motif containing 1
  membrane associated ring-CH-type finger 7
  NBPF member 19
  notch 2 N-terminal like A
  ring finger protein 111
  SET domain containing 7, histone lysine methyltransferase
  SMAD specific E3 ubiquitin protein ligase 2
  SURP and G-patch domain containing 1
  tetratricopeptide repeat domain 9C
  tripartite motif containing 8
  ubiquitin conjugating enzyme E2 Q2
  ubiquitin conjugating enzyme E2 W

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.