EDARADD, EDAR associated death domain

EDARADD, EDAR associated death domain

• This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ECTD11A, ECTD11B, ED3, EDA3, ectodysplasin-A receptor-associated adapter protein, EDAR-associated death domain protein, crinkled homolog, ectodysplasia A receptor associated death domain,)
• NCBI Gene ID: 128178
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WWZ3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

EDAR associated death domain interacts with:

• EDAR associated death domain
  SNF2 histone linker PHD RING helicase

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