CHCHD3, coiled-coil-helix-coiled-coil-helix domain containing 3

CHCHD3, coiled-coil-helix-coiled-coil-helix domain containing 3

• The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

• Gene Synonyms (MICOS complex subunit MIC19, coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial, mitochondrial contact site and cristae organizing system subunit 19, mitochondrial inner membrane organizing system 3, protein phosphatase 1, regulatory subunit 22, MICOS19, MINOS3, Mic19, PPP1R22,)
• NCBI Gene ID: 54927
• Species: Homo sapiens (Human)
• UNIPROT ID#>>C9JRZ6
  UNIPROT ID#>>Q9NX63
  UNIPROT ID#>>B7Z1X9
  UNIPROT ID#>>A4D1N4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

coiled-coil-helix-coiled-coil-helix domain containing 3 interacts with:

• aarF domain containing kinase 1
  apolipoprotein O like
  armadillo repeat containing 7
  C2 calcium dependent domain containing 6
  calmodulin-like 3
  centrosomal protein 72
  chibby family member 2
  chromosome 15 open reading frame 48
  coiled-coil domain containing 33
  coiled-coil domain containing 8
  cysteine rich tail 1
  cytochrome c oxidase assembly factor COX14
  DnaJ heat shock protein family (Hsp40) member C11
  dual specificity phosphatase 22
  EF-hand domain containing 1
  egl-9 family hypoxia inducible factor 3
  enkurin domain containing 1
  FA complementation group L
  G protein-coupled receptor associated sorting protein 2
  germ cell-less 2, spermatogenesis associated
  heterogeneous nuclear ribonucleoprotein F
  histone deacetylase 8
  keratin 40
  keratin associated protein 4-12
  leucine rich repeat containing 59
  leucine zipper tumor suppressor 2
  limb development membrane protein 1 like
  MAU2 sister chromatid cohesion factor
  membrane magnesium transporter 1
  mitochondrial contact site and cristae organizing system subunit 10
  mitochondrial contact site and cristae organizing system subunit 13
  myosin XIX
  NBPF member 19
  notch 2 N-terminal like A
  N-terminal glutamine amidase 1
  NUT midline carcinoma family member 1
  OCIA domain containing 1
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  plasminogen receptor with a C-terminal lysine
  pleckstrin homology domain containing A4
  RAB3A interacting protein
  RecQ protein-like 4
  regulator of microtubule dynamics 3
  RPGR interacting protein 1
  SAMM50 sorting and assembly machinery component
  sideroflexin 1
  solute carrier family 25 member 46
  SSX family member 2 interacting protein
  translocase of outer mitochondrial membrane 22
  USH1 protein network component harmonin binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.