PDPR, pyruvate dehydrogenase phosphatase regulatory subunit

PDPR, pyruvate dehydrogenase phosphatase regulatory subunit

• Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

• Gene Synonyms (pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial, PDP3,)
• NCBI Gene ID: 55066
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NCN5
  UNIPROT ID#>>A8MT40
  UNIPROT ID#>>B4DZL5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pyruvate dehydrogenase phosphatase regulatory subunit interacts with:

• arginyl-tRNA synthetase 2, mitochondrial
  egl-9 family hypoxia inducible factor 3
  glutamyl-tRNA amidotransferase subunit C
  NADH:ubiquinone oxidoreductase core subunit S7
  Nanog homeobox
  pregnancy specific beta-1-glycoprotein 8
  solute carrier family 25 member 41
  tRNA methyltransferase 1
  TSC22 domain family member 4
  TSPY like 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.