OTUB1, OTU deubiquitinase, ubiquitin aldehyde binding 1

OTUB1, OTU deubiquitinase, ubiquitin aldehyde binding 1

• The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HSPC263, OTB1, OTU1, ubiquitin thioesterase OTUB1, OTU domain, ubiquitin aldehyde binding 1, OTU domain-containing ubiquitin aldehyde-binding protein 1, OTU-domain Ubal-binding 1, deubiquitinating enzyme OTUB1, otubain-1, ubiquitin-specific protease otubain 1, ubiquitin-specific-processing protease OTUB1,)
• NCBI Gene ID: 55611
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96FW1
  UNIPROT ID#>>B3KUV5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

OTU deubiquitinase, ubiquitin aldehyde binding 1 interacts with:

• acylglycerol kinase
  ATP synthase membrane subunit DAPIT
  chromosome X open reading frame 56
  cytoplasmic polyadenylation element binding protein 2
  DEAD-box helicase 24
  DEAD-box helicase 54
  DEP domain containing MTOR interacting protein
  dual specificity phosphatase 21
  dual specificity phosphatase 28
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 136 member A
  FLYWCH family member 2
  hypoxia inducible factor 1 subunit alpha inhibitor
  ILK associated serine/threonine phosphatase
  matrix AAA peptidase interacting protein 1
  methylcrotonoyl-CoA carboxylase 2
  mitochondrial antiviral signaling protein
  myotrophin
  NmrA like redox sensor 1
  O-sialoglycoprotein endopeptidase
  potassium channel tetramerization domain containing 12
  praja ring finger ubiquitin ligase 1
  regulator of chromosome condensation 2
  regulatory factor X7
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger protein 126
  ring finger protein 128
  serine protease 38
  SHANK associated RH domain interactor
  SRP receptor subunit beta
  STAM binding protein like 1
  taxilin alpha
  telomerase RNA component interacting RNase
  translocase of outer mitochondrial membrane 22
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 63
  ubiquitin conjugating enzyme E2 Z
  ubiquitin domain containing 1
  ubiquitin specific peptidase 28
  zinc finger CCCH-type containing, antiviral 1 like
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.