RNF128, ring finger protein 128

RNF128, ring finger protein 128

• The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF128, RING-type E3 ubiquitin transferase RNF128, gene related to anergy in lymphocytes protein, ring finger protein 128, E3 ubiquitin protein ligase, GRAIL,)
• NCBI Gene ID: 79589
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TEB7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 128 interacts with:

• centrosomal protein 76
  Rho GDP dissociation inhibitor (GDI) alpha
  ring finger protein 128

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.