PBXIP1, PBX homeobox interacting protein 1

PBXIP1, PBX homeobox interacting protein 1

• The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]

• Gene Synonyms (HPIP, pre-B-cell leukemia transcription factor-interacting protein 1, hematopoietic PBX-interacting protein, pre-B-cell leukemia homeobox interacting protein 1,)
• NCBI Gene ID: 57326
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96AQ6
  UNIPROT ID#>>B4E0K4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PBX homeobox interacting protein 1 interacts with:

• catechol-O-methyltransferase domain containing 1
  C-type lectin domain family 12 member A
  developmental pluripotency associated 2
  germ cell-less 1, spermatogenesis associated
  keratin associated protein 10-6
  lebercilin LCA5 like
  metallophosphoesterase 1
  protein phosphatase targeting COQ7
  pterin-4 alpha-carbinolamine dehydratase 2
  solute carrier family 25 member 28
  TGF-beta activated kinase 1 (MAP3K7) binding protein 3
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.