TAB3, TGF-beta activated kinase 1 (MAP3K7) binding protein 3

TAB3, TGF-beta activated kinase 1 (MAP3K7) binding protein 3

• The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, NF-kappa-B-activating protein 1, NFkB activating protein 1, TAB-3, TAK1-binding protein 3, TGF-beta activated kinase 1 and MAP3K7 binding protein 3, TGF-beta-activated kinase 1-binding protein 3, mitogen-activated protein kinase kinase kinase 7 interacting protein 3, MAP3K7IP3, NAP1,)
• NCBI Gene ID: 257397
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N5C8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TGF-beta activated kinase 1 (MAP3K7) binding protein 3 interacts with:

• centrosomal protein 57 like 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 3

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