RNF213, ring finger protein 213

RNF213, ring finger protein 213

• This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

• Gene Synonyms (ALO17, C17orf27, KIAA1618, MYMY2, MYSTR, NET57, E3 ubiquitin-protein ligase RNF213, ALK lymphoma oligomerization partner on chromosome 17, RING-type E3 ubiquitin transferase RNF213, mysterin,)
• NCBI Gene ID: 57674
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q63HN8
  UNIPROT ID#>>A0A0A0MTC1
  UNIPROT ID#>>A0A0A0MTR7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 213 interacts with:

• AHNAK nucleoprotein 2
  chromobox 2
  copine 8
  delta like non-canonical Notch ligand 2
  keratin 40
  metadherin
  placenta associated 9
  ribonuclease H2 subunit B
  ribosomal protein L35
  ring finger protein 123
  ring finger protein 213
  SIGLEC family like 1
  UBX domain protein 11
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.