MARK4, microtubule affinity regulating kinase 4

MARK4, microtubule affinity regulating kinase 4

• This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D, MAP/microtubule affinity-regulating kinase 4, MAP/microtubule affinity-regulating kinase like 1, MARK4 serine/threonine protein kinase, epididymis secretory sperm binding protein,)
• NCBI Gene ID: 57787
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96L34
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

microtubule affinity regulating kinase 4 interacts with:

• dedicator of cytokinesis 7
  HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
  keratin 40
  microtubule affinity regulating kinase 4
  myosin XVIIIA
  NLR family pyrin domain containing 3
  notch 2 N-terminal like A
  potassium channel tetramerization domain containing 20
  suppressor of glucose, autophagy associated 1
  tubulin beta class I

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.