NOD2, nucleotide binding oligomerization domain containing 2

NOD2, nucleotide binding oligomerization domain containing 2

• This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

• Gene Synonyms (nucleotide-binding oligomerization domain-containing protein 2, NLR family, CARD domain containing 2, NOD-like receptor C2, caspase recruitment domain family, member 15, caspase recruitment domain protein 15, caspase recruitment domain-containing protein 15, inflammatory bowel disease protein 1, nucleotide-binding oligomerization domain 2, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2, ACUG, BLAU, BLAUS, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, YAOS,)
• NCBI Gene ID: 64127
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A286YF65
  UNIPROT ID#>>Q9HC29
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nucleotide binding oligomerization domain containing 2 interacts with:

• caspase 12 (gene/pseudogene)
  charged multivesicular body protein 4B
  chromosome 10 open reading frame 67
  dedicator of cytokinesis 7
  IKBKB interacting protein
  immunity related GTPase M
  leucine rich adaptor protein 1 like
  N-acetyltransferase 16 (putative)
  nucleotide binding oligomerization domain containing 2
  SHANK associated RH domain interactor
  tripartite motif containing 41

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.