PLEKHG2, pleckstrin homology and RhoGEF domain containing G2

PLEKHG2, pleckstrin homology and RhoGEF domain containing G2

• The protein encoded by this gene is a RhoGTPase that can activate CDC42 by promoting exchange of GDP for GTP on CDC42. The encoded protein is activated by binding to the beta and gamma subunits of heterotrimeric guanine nucleotide-binding protein. Defects in this gene have been associated with leukodystrophy and acquired microcephaly with or without dystonia. [provided by RefSeq, May 2017]

• Gene Synonyms (pleckstrin homology domain-containing family G member 2, PH domain-containing family G member 2, common-site lymphoma/leukemia guanine nucleotide exchange factor, pleckstrin homology domain containing, family G (with RhoGef domain) member 2, ARHGEF42, CLG, CTB-60E11.4, LDAMD,)
• NCBI Gene ID: 64857
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H7P9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pleckstrin homology and RhoGEF domain containing G2 interacts with:

• dynein light chain roadblock-type 1

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