MAP3K12, mitogen-activated protein kinase kinase kinase 12

MAP3K12, mitogen-activated protein kinase kinase kinase 12

• This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

• Gene Synonyms (mitogen-activated protein kinase kinase kinase 12, MAPK-upstream kinase, dual leucine zipper bearing kinase, dual leucine zipper kinase DLK, leucine zipper protein kinase, mixed lineage kinase, protein kinase MUK, DLK, MEKK12, MUK, ZPK, ZPKP1,)
• NCBI Gene ID: 7786
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RAY5
  UNIPROT ID#>>Q12852
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase 12 interacts with:

• FRA10A associated CGG repeat 1
  MAP3K12 binding inhibitory protein 1
  metadherin
  mitogen-activated protein kinase 8 interacting protein 1
  mitogen-activated protein kinase 8 interacting protein 2
  SH3 domain containing ring finger 1
  TSC22 domain family member 1

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