SH3RF1, SH3 domain containing ring finger 1

SH3RF1, SH3 domain containing ring finger 1

• This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]

• Gene Synonyms (POSH, RNF142, SH3MD2, E3 ubiquitin-protein ligase SH3RF1, RING-type E3 ubiquitin transferase SH3RF1, SH3 domain-containing RING finger protein 1, SH3 multiple domains 2, SH3 multiple domains protein 2, plenty of SH3 domains, plenty of SH3s, putative E3 ubiquitin-protein ligase SH3RF1, ring finger protein 142,)
• NCBI Gene ID: 57630
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z6J0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SH3 domain containing ring finger 1 interacts with:

• ataxin 7 like 2
  DMRT like family B with proline rich C-terminal 1
  ELL associated factor 1
  gametogenetin
  maturin, neural progenitor differentiation regulator homolog
  neutrophil cytosolic factor 1
  NFKB inhibitor delta
  NHS like 2
  nuclear assembly factor 1 ribonucleoprotein
  one cut homeobox 3
  PML-RARA regulated adaptor molecule 1
  proline rich 20A
  proline rich 20B
  proline rich 20C
  proline rich 20D
  proline rich 20E
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger protein 208
  SH2 domain containing 4A
  SH3 domain containing 19
  SH3 domain containing ring finger 1
  SH3 domain containing ring finger 2
  synaptopodin 2 like
  WD repeat domain 62
  xin actin binding repeat containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.