ADAM12, ADAM metallopeptidase domain 12

ADAM12, ADAM metallopeptidase domain 12

• This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

• Gene Synonyms (disintegrin and metalloproteinase domain-containing protein 12, meltrin-alpha, metalloprotease-disintegrin 12 transmembrane, ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA,)
• NCBI Gene ID: 8038
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43184
  UNIPROT ID#>>A8K6G4
  UNIPROT ID#>>U5NE98
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ADAM metallopeptidase domain 12 interacts with:

• ADAMTS like 4
  cysteine rich tail 1
  endothelial cell specific molecule 1
  follistatin like 3
  four and a half LIM domains 5
  guanylyl cyclase domain containing 1
  keratin associated protein 10-8
  keratin associated protein 1-1
  keratin associated protein 12-2
  keratin associated protein 1-3
  keratin associated protein 3-1
  keratin associated protein 3-2
  keratin associated protein 4-12
  keratin associated protein 5-6
  keratin associated protein 6-2
  keratin associated protein 9-2
  keratin associated protein 9-8
  late cornified envelope 5A
  mitogen-activated protein kinase binding protein 1
  NBPF member 19
  notch 2 N-terminal like A
  protein kinase C and casein kinase substrate in neurons 3
  reversion inducing cysteine rich protein with kazal motifs
  SH3 domain containing 19
  sprouty RTK signaling antagonist 1
  sprouty RTK signaling antagonist 4
  transcription factor AP-2 delta
  tyrosyl-tRNA synthetase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.