RECK, reversion inducing cysteine rich protein with kazal motifs

RECK, reversion inducing cysteine rich protein with kazal motifs

• The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

• Gene Synonyms (reversion-inducing cysteine-rich protein with Kazal motifs, membrane-anchored glycoprotein (metastasis and invasion), suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs), suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs), suppressor of tumorigenicity 15 protein, ST15,)
• NCBI Gene ID: 8434
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K9D8
  UNIPROT ID#>>O95980
  UNIPROT ID#>>Q6P9E2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

reversion inducing cysteine rich protein with kazal motifs interacts with:

• Bcl2 modifying factor
  cap binding complex dependent translation initiation factor
  centrosomal protein 44
  chromosome 22 open reading frame 39
  cysteine rich tail 1
  DISC1 scaffold protein
  EF-hand domain containing 2
  glutaredoxin 3
  inhibitor of CDK, cyclin A1 interacting protein 1
  kelch like ECH associated protein 1
  kelch like family member 20
  keratin 40
  keratin associated protein 10-8
  keratin associated protein 13-2
  keratin associated protein 26-1
  keratin associated protein 3-1
  melanophilin
  methylcrotonoyl-CoA carboxylase 2
  NBPF member 19
  notch 2 N-terminal like A
  nudix hydrolase 16 like 1
  oxoeicosanoid receptor 1
  scavenger receptor cysteine rich family member with 4 domains
  splA/ryanodine receptor domain and SOCS box containing 2
  tektin 4
  tripartite motif containing 39
  tripartite motif containing 69
  USH1 protein network component harmonin binding protein 1
  zinc finger protein 438
  zinc finger protein 704

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.