CDC45, cell division cycle 45

CDC45, cell division cycle 45

• The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene Synonyms (cell division control protein 45 homolog, CDC45 cell division cycle 45 homolog, CDC45 cell division cycle 45-like, CDC45-related protein, cell division cycle 45 homolog, cell division cycle 45-like 2, human CDC45, CDC45L, CDC45L2, MGORS7, PORC-PI-1,)
• NCBI Gene ID: 8318
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75419
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cell division cycle 45 interacts with:

• AAR2 splicing factor
  actin related protein 1A
  calcium/calmodulin dependent protein kinase IG
  centrosomal protein 55
  CTD phosphatase subunit 1
  cullin 3
  D-aminoacyl-tRNA deacylase 1
  DDB1 and CUL4 associated factor 15
  DNA topoisomerase II binding protein 1
  dual specificity phosphatase 10
  egl-9 family hypoxia inducible factor 3
  establishment of sister chromatid cohesion N-acetyltransferase 2
  F-box protein 6
  GINS complex subunit 4
  H3 clustered histone 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  L3MBTL histone methyl-lysine binding protein 1
  minichromosome maintenance 10 replication initiation factor
  origin recognition complex subunit 3
  origin recognition complex subunit 6
  PDS5 cohesin associated factor B
  pleckstrin homology domain containing A4
  RAB4B, member RAS oncogene family
  RecQ like helicase 4
  trafficking protein particle complex 3
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.