LNX1, ligand of numb-protein X 1

LNX1, ligand of numb-protein X 1

• This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase LNX, PDZ domain-containing ring finger protein 2, RING-type E3 ubiquitin transferase LNX, ligand of numb-protein X 1, E3 ubiquitin protein ligase, multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX, numb-binding protein 1, LNX, MPDZ, PDZRN2,)
• NCBI Gene ID: 84708
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TBB1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ligand of numb-protein X 1 interacts with:

• alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  aminoacylase 3
  ATP synthase mitochondrial F1 complex assembly factor 2
  BEN domain containing 7
  C1q and TNF related 1
  calcium and integrin binding family member 3
  calcium release activated channel regulator 2B
  calcium/calmodulin dependent protein kinase II inhibitor 2
  cation channel sperm associated auxiliary subunit delta
  chibby family member 2
  CKLF like MARVEL transmembrane domain containing 5
  coiled-coil domain containing 114
  coiled-coil domain containing 88B
  collagen and calcium binding EGF domains 1
  copine 2
  cysteine rich tail 1
  deltex E3 ubiquitin ligase 2
  DENN domain containing 1B
  deuterosome assembly protein 1
  DPY30 domain containing 1
  dual specificity phosphatase 29
  ecotropic viral integration site 5 like
  egl-9 family hypoxia inducible factor 3
  eukaryotic elongation factor 2 lysine methyltransferase
  exocyst complex component 8
  family with sequence similarity 124 member A
  family with sequence similarity 9 member B
  fibronectin type III and SPRY domain containing 2
  forkhead box P2
  G protein-coupled receptor 142
  gap junction protein delta 4
  growth arrest specific 2 like 2
  HEXIM P-TEFb complex subunit 2
  highly divergent homeobox
  immunoglobulin superfamily member 5
  INO80 complex subunit E
  inositol hexakisphosphate kinase 3
  INSC spindle orientation adaptor protein
  interactor of HORMAD1 1
  keratin associated protein 10-8
  keratin associated protein 12-3
  keratin associated protein 13-3
  keratin associated protein 2-3
  keratin associated protein 2-4
  keratin associated protein 4-2
  keratin associated protein 6-3
  keratinocyte proline rich protein
  KH RNA binding domain containing, signal transduction associated 2
  kinesin family member 24
  kinesin family member 7
  leucine rich repeat containing 3B
  leucine rich repeat containing 73
  ligand of numb-protein X 1
  ligand of numb-protein X 2
  LON peptidase N-terminal domain and ring finger 1
  lysocardiolipin acyltransferase 1
  MAGE family member B18
  methyltransferase like 21A
  Morf4 family associated protein 1 like 1
  multivesicular body subunit 12B
  musculoskeletal, embryonic nuclear protein 1
  NBPF member 19
  NKD inhibitor of WNT signaling pathway 2
  notch 2 N-terminal like A
  nuclear RNA export factor 2B
  nudix hydrolase 14
  ORMDL sphingolipid biosynthesis regulator 1
  ORMDL sphingolipid biosynthesis regulator 3
  PNMA family member 5
  potassium channel tetramerization domain containing 1
  potassium channel tetramerization domain containing 13
  potassium channel tetramerization domain containing 6
  potassium channel tetramerization domain containing 7
  receptor accessory protein 6
  ribosomal oxygenase 2
  RNA binding motif protein 12B
  RNA binding motif protein 20
  RNA binding motif protein Y-linked family 1 member F
  RNA binding motif protein Y-linked family 1 member J
  RUN and FYVE domain containing 4
  SAGA complex associated factor 29
  SH3 and cysteine rich domain 2
  sidekick cell adhesion molecule 1
  sodium channel and clathrin linker 1
  suppressor APC domain containing 1
  synaptonemal complex central element protein 1 like
  tektin 4
  TRAF interacting protein with forkhead associated domain
  transglutaminase 7
  transmembrane p24 trafficking protein 4
  transmembrane protein 239
  tripartite motif containing 42
  tripartite motif containing 50
  tripartite motif containing 60
  tubulin folding cofactor E like
  ubiquitin specific peptidase 54
  uridine phosphorylase 2
  vasorin
  vimentin type intermediate filament associated coiled-coil protein
  zinc binding alcohol dehydrogenase domain containing 2
  zinc finger and BTB domain containing 8A
  zinc finger and BTB domain containing 8B
  zinc finger CCHC-type and RNA binding motif containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.