CRADD, CASP2 and RIPK1 domain containing adaptor with death domain

CRADD, CASP2 and RIPK1 domain containing adaptor with death domain

• This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

• Gene Synonyms (death domain-containing protein CRADD, CRADD/LYZ fusion, RIP-associated ICH1/CED3-homologous protein with death domain, caspase and RIP adaptor with death domain, death adaptor molecule RAIDD, death domain containing protein CRADD, MRT34, RAIDD,)
• NCBI Gene ID: 8738
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78560
  UNIPROT ID#>>Q53XL1
  UNIPROT ID#>>F8VV49
  UNIPROT ID#>>F8VVY5
  UNIPROT ID#>>B4DJT6
  UNIPROT ID#>>F5H7C2
  UNIPROT ID#>>Q8IY43
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CASP2 and RIPK1 domain containing adaptor with death domain interacts with:

• adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
  Bardet-Biedl syndrome 5
  coiled-coil serine rich protein 2
  dicarbonyl and L-xylulose reductase
  ergosterol biosynthesis 28 homolog
  ligand dependent nuclear receptor interacting factor 1
  p53-induced death domain protein 1
  potassium channel tetramerization domain containing 9
  solute carrier family 35 member A3
  tripartite motif containing 54
  WNT inhibitory factor 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.