EIF2B4, eukaryotic translation initiation factor 2B subunit delta

EIF2B4, eukaryotic translation initiation factor 2B subunit delta

• Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (translation initiation factor eIF-2B subunit delta, eIF-2B GDP-GTP exchange factor subunit delta, eukaryotic translation initiation factor 2B subunit 4 delta, eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa, translation initiation factor eIF-2b delta subunit, EIF-2B, EIF2B, EIF2Bdelta,)
• NCBI Gene ID: 8890
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F8W8L6
  UNIPROT ID#>>Q9HBP7
  UNIPROT ID#>>B4DUP5
  UNIPROT ID#>>E7ERK9
  UNIPROT ID#>>Q71US4
  UNIPROT ID#>>Q9UI10
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 2B subunit delta interacts with:

• autophagy related 16 like 1
  basic leucine zipper and W2 domains 2
  carbonic anhydrase 14
  decapping mRNA 1A
  developmental pluripotency-associated 3
  dual specificity phosphatase 22
  EBNA1 binding protein 2
  elongation factor Tu GTP binding domain containing 2
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 2 subunit beta
  eukaryotic translation initiation factor 2B subunit beta
  eukaryotic translation initiation factor 2B subunit delta
  eukaryotic translation initiation factor 2B subunit epsilon
  eukaryotic translation initiation factor 2B subunit gamma
  exosome component 4
  F-box and WD repeat domain containing 7
  frizzled class receptor 10
  FtsJ RNA 2'-O-methyltransferase 3
  immunoglobulin superfamily member 8
  limb development membrane protein 1 like
  membrane spanning 4-domains A4A
  metaxin 2
  mitochondrial calcium uniporter
  nectin cell adhesion molecule 4
  NOP56 ribonucleoprotein
  opsin 3
  pleckstrin homology domain containing A4
  PNKD metallo-beta-lactamase domain containing
  proton activated chloride channel 1
  RIO kinase 1
  SIGLEC family like 1
  signal recognition particle 72
  single-pass membrane protein with aspartate rich tail 1
  solute carrier family 15 member 3
  syntaxin 12
  testin LIM domain protein
  TNF superfamily member 13b
  tripartite motif containing 28
  unc-93 homolog B1, TLR signaling regulator
  vesicle transport through interaction with t-SNAREs 1B
  vir like m6A methyltransferase associated
  zinc finger protein 622

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.