ARHGEF1, Rho guanine nucleotide exchange factor 1

ARHGEF1, Rho guanine nucleotide exchange factor 1

• Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (rho guanine nucleotide exchange factor 1, 115 kDa guanine nucleotide exchange factor, 115-kD protein, Lsc homolog, Rho guanine nucleotide exchange factor (GEF) 1, p115RhoGEF, GEF1, IMD62, LBCL2, LSC, P115-RHOGEF, SUB1.5,)
• NCBI Gene ID: 9138
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R0R1
  UNIPROT ID#>>Q92888
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho guanine nucleotide exchange factor 1 interacts with:

• activator of HSP90 ATPase activity 1
  connector enhancer of kinase suppressor of Ras 1
  cyclase associated actin cytoskeleton regulatory protein 2
  cyclin J like
  cytoplasmic FMR1 interacting protein 1
  defective in cullin neddylation 1 domain containing 1
  elongation factor Tu GTP binding domain containing 2
  G protein subunit alpha 13
  limb development membrane protein 1 like
  methylphosphate capping enzyme
  pleckstrin homology domain containing A4
  Rho guanine nucleotide exchange factor 1
  SH3 domain containing kinase binding protein 1
  SNW domain containing 1
  STE20 like kinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.