SLC9A3R2, SLC9A3 regulator 2

SLC9A3R2, SLC9A3 regulator 2

• This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

• Gene Synonyms (Na(+)/H(+) exchange regulatory cofactor NHE-RF2, NHE3 kinase A regulatory protein E3KARP, NHE3 regulatory factor 2, SRY-interacting protein 1, sodium/hydrogen exchanger 3 kinase A regulatory protein, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2, solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2, solute carrier family 9 isoform A3 regulatory factor 2, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2, tyrosine kinase activator protein 1, E3KARP, NHE3RF2, NHERF-2, NHERF2, OCTS2, SIP-1, SIP1, TKA-1,)
• NCBI Gene ID: 9351
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15599
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SLC9A3 regulator 2 interacts with:

• Abelson helper integration site 1
  ataxin 2 like
  ATP binding cassette subfamily C member 4
  cadherin related 23
  COP9 signalosome subunit 8
  DLG associated protein 4
  kinesin associated protein 3
  kinesin family member 3A
  kinesin family member 3B
  LSM12 homolog
  melanocortin 2 receptor accessory protein 2
  methionyl-tRNA synthetase 2, mitochondrial
  NPC intracellular cholesterol transporter 2
  nucleolar and spindle associated protein 1
  nudix hydrolase 19
  nudix hydrolase 5
  OTU deubiquitinase 7B
  PH domain and leucine rich repeat protein phosphatase 1
  PH domain and leucine rich repeat protein phosphatase 2
  phosphatase and tensin homolog
  platelet derived growth factor receptor, beta polypeptide
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 5
  progesterone immunomodulatory binding factor 1
  protein tyrosine phosphatase receptor type Q
  Rac/Cdc42 guanine nucleotide exchange factor 6
  radixin
  reticulon 4
  Rho GTPase activating protein 44
  septin 11
  serum/glucocorticoid regulated kinase family member 3
  SIN3 transcription regulator family member A
  solute carrier family 22 member 9
  solute carrier organic anion transporter family member 3A1
  TBC1 domain family member 10A
  TNF receptor associated factor 4
  translation machinery associated 16 homolog
  translational activator of cytochrome c oxidase I
  translocase of outer mitochondrial membrane 40
  USH1 protein network component harmonin
  WASP family member 3
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing transcription regulator 1
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.