UBE4A, ubiquitination factor E4A

UBE4A, ubiquitination factor E4A

• This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

• Gene Synonyms (ubiquitin conjugation factor E4 A, RING-type E3 ubiquitin transferase E4 A, ubiquitination factor E4A (UFD2 homolog, yeast), E4, UBOX2, UFD2,)
• NCBI Gene ID: 9354
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14139
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitination factor E4A interacts with:

• chromobox 7
  developmental pluripotency-associated 3
  FAM3 metabolism regulating signaling molecule C
  forkhead box B1
  forkhead box I2
  forkhead box Q1
  inositol hexakisphosphate kinase 1
  leucine rich repeat transmembrane neuronal 1
  mitochondrial antiviral signaling protein
  OTU deubiquitinase with linear linkage specificity like
  poly(ADP-ribose) polymerase family member 16
  protein tyrosine phosphatase 4A3
  selenoprotein S
  SIGLEC family like 1
  synaptic vesicle glycoprotein 2C
  ubiquitin conjugating enzyme E2 D4 (putative)
  UBX domain protein 4
  vir like m6A methyltransferase associated
  V-set and immunoglobulin domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.