TP53I3, tumor protein p53 inducible protein 3

TP53I3, tumor protein p53 inducible protein 3

• The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

• Gene Synonyms (quinone oxidoreductase PIG3, p53-induced gene 3 protein, quinone oxidoreductase homolog, PIG3,)
• NCBI Gene ID: 9540
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DMQ7
  UNIPROT ID#>>Q53FA7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tumor protein p53 inducible protein 3 interacts with:

• FUN14 domain containing 2
  MTOR associated protein, eak-7 homolog
  ubiquitin protein ligase E3 component n-recognin 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.