RNF14, ring finger protein 14

RNF14, ring finger protein 14

• The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF14, androgen receptor associated protein 54, ARA54, HFB30, HRIHFB2038, TRIAD2,)
• NCBI Gene ID: 9604
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z229
  UNIPROT ID#>>Q9UBS8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 14 interacts with:

• DET1 partner of COP1 E3 ubiquitin ligase
  lymphoid enhancer binding factor 1
  patatin like phospholipase domain containing 7
  PHD finger protein 7
  protocadherin 1
  ring finger protein 14
  terminal nucleotidyltransferase 5A
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 U
  ubiquitin conjugating enzyme E2 W

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.