ISG15, ISG15 ubiquitin like modifier

ISG15, ISG15 ubiquitin like modifier

• The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

• Gene Synonyms (ubiquitin-like protein ISG15, interferon, alpha-inducible protein (clone IFI-15K), interferon-induced 17-kDa/15-kDa protein, interferon-stimulated protein, 15 kDa, ubiquitin cross-reactive protein, G1P2, IFI15, IMD38, IP17, UCRP, hUCRP,)
• NCBI Gene ID: 9636
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P05161
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ISG15 ubiquitin like modifier interacts with:

• acyl-CoA thioesterase 8
  AHNAK nucleoprotein
  ataxin 2 like
  ATP binding cassette subfamily F member 2
  AT-rich interaction domain 5B
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  charged multivesicular body protein 5
  cyclin L1
  DEAD-box helicase 17
  DEAD-box helicase 42
  DEP domain containing 7
  destrin, actin depolymerizing factor
  DExD/H-box helicase 58
  DnaJ heat shock protein family (Hsp40) member B4
  epiplakin 1
  family with sequence similarity 120C
  G3BP stress granule assembly factor 1
  glucosidase II alpha subunit
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  helicase with zinc finger 2
  histone deacetylase 6
  interferon induced protein with tetratricopeptide repeats 5
  interferon lambda 3
  lectin, mannose binding 2
  leucine aminopeptidase 3
  leucine rich repeat containing 25
  methylphosphate capping enzyme
  myoferlin
  nucleoporin 43
  palladin, cytoskeletal associated protein
  phenylalanyl-tRNA synthetase 2, mitochondrial
  phosphoglycerate dehydrogenase
  PYM homolog 1, exon junction complex associated factor
  queuine tRNA-ribosyltransferase accessory subunit 2
  receptor for activated C kinase 1
  retinol dehydrogenase 11
  RNA binding motif protein 15B
  serine/threonine kinase 38
  SERPINE1 mRNA binding protein 1
  SIN3 transcription regulator family member A
  small nuclear ribonucleoprotein U5 subunit 200
  splicing factor 3b subunit 4
  SUMO specific peptidase 1
  tropomodulin 3
  tyrosine kinase non receptor 2
  ubiquitin associated protein 2 like
  ubiquitin specific peptidase 18
  ubiquitin specific peptidase 21
  UTP4 small subunit processome component
  WD repeat domain 1
  WD repeat domain 33
  YTH domain containing 1
  YTH N6-methyladenosine RNA binding protein 3
  zinc finger CCCH-type containing 15
  zinc finger CCCH-type containing, antiviral 1
  zinc finger protein 281
  zinc finger protein 318

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.