SF3B4, splicing factor 3b subunit 4

SF3B4, splicing factor 3b subunit 4

• This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AFD1, Hsh49, SAP49, SF3b49, splicing factor 3B subunit 4, SAP 49, SF3b50, pre-mRNA-splicing factor SF3b 49 kDa subunit, spliceosomal protein, spliceosome-associated protein (U2 snRNP), spliceosome-associated protein 49, splicing factor 3b, subunit 4, 49kD, splicing factor 3b, subunit 4, 49kDa,)
• NCBI Gene ID: 10262
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15427
  UNIPROT ID#>>B3KUJ0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

splicing factor 3b subunit 4 interacts with:

• acetyl-CoA acyltransferase 2
  BAR/IMD domain containing adaptor protein 2
  BCAS2 pre-mRNA processing factor
  bromodomain containing 7
  calcium homeostasis endoplasmic reticulum protein
  coiled-coil domain containing 97
  COP9 signalosome subunit 5
  COPI coat complex subunit epsilon
  cullin associated and neddylation dissociated 1
  CWC15 spliceosome associated protein homolog
  CWF19 like cell cycle control factor 2
  DEAD-box helicase 17
  DEAD-box helicase 42
  GLI pathogenesis related 1
  heat shock protein family B (small) member 7
  heterogeneous nuclear ribonucleoprotein U like 1
  La ribonucleoprotein 7, transcriptional regulator
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 17
  MINDY lysine 48 deubiquitinase 4
  M-phase specific PLK1 interacting protein
  negative regulator of ubiquitin like proteins 1
  PHD finger protein 5A
  pleckstrin homology domain containing A4
  poly(A) binding protein interacting protein 1
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 8
  protein phosphatase 1 regulatory subunit 16B
  protein phosphatase 4 regulatory subunit 2
  ribonuclease P and MRP subunit p25
  ribosome biogenesis regulator 1 homolog
  RIO kinase 1
  RNA binding motif protein X-linked
  RNA guanine-7 methyltransferase activating subunit
  serine/arginine repetitive matrix 2
  SID1 transmembrane family, member 2
  small ubiquitin like modifier 4
  SNW domain containing 1
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  splicing factor 3a, subunit 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing factor 3b subunit 5
  splicing factor 3b subunit 6
  SRA stem-loop interacting RNA binding protein
  SRP receptor subunit beta
  SRSF protein kinase 3
  SS18L1 subunit of BAF chromatin remodeling complex
  survival motor neuron domain containing 1
  SUZ12 polycomb repressive complex 2 subunit
  TNFAIP3 interacting protein 2
  trafficking from ER to golgi regulator
  transcription elongation regulator 1
  transducin beta like 2
  translocase of inner mitochondrial membrane 13
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin associated and SH3 domain containing A
  ubiquitination factor E4B
  vir like m6A methyltransferase associated
  WD repeat domain 77
  WD repeat domain 83
  WW domain binding protein 4
  WW domain containing E3 ubiquitin protein ligase 2
  YTH N6-methyladenosine RNA binding protein 1
  zinc finger CCHC-type containing 10
  zinc finger protein 48

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.