BCL2L10, BCL2 like 10

BCL2L10, BCL2 like 10

• The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

• Gene Synonyms (bcl-2-like protein 10, BCL2-like 10 (apoptosis facilitator), anti-apoptotic protein NrH, apoptosis regulator Bcl-B, death inducer binding to vBcl-2 and Apaf-1, BCL-B, Boo, Diva, bcl2-L-10,)
• NCBI Gene ID: 10017
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HD36
  UNIPROT ID#>>H0YMD5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCL2 like 10 interacts with:

• BCL2 like 10
  BCL2 like 11
  Bcl2 modifying factor
  sterile alpha motif domain containing 4B
  transmembrane protein 200A
  ubiquilin 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.