STAM2, signal transducing adaptor molecule 2

STAM2, signal transducing adaptor molecule 2

• The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (Hbp, STAM2A, STAM2B, signal transducing adapter molecule 2, HSE1 homolog, Hrs-binding protein, STAM-2, STAM-like protein containing SH3 and ITAM domains 2, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2,)
• NCBI Gene ID: 10254
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75886
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

signal transducing adaptor molecule 2 interacts with:

• 5'-3' exoribonuclease 1
  arrestin domain containing 3
  Bet1 golgi vesicular membrane trafficking protein
  chromobox 5
  component of oligomeric golgi complex 7
  DDB1 and CUL4 associated factor 8
  Fas binding factor 1
  itchy E3 ubiquitin protein ligase
  kelch like family member 42
  kinesin family member 15
  L3MBTL histone methyl-lysine binding protein 2
  mindbomb E3 ubiquitin protein ligase 1
  PHD finger protein 10
  pleckstrin homology domain containing B2
  protein phosphatase 1 regulatory subunit 13B
  protein tyrosine phosphatase non-receptor type 23
  rhomboid 5 homolog 2
  ring finger protein 11
  SEC31 homolog A, COPII coat complex component
  SH2 domain containing 4A
  splicing factor 3a subunit 3
  STAM binding protein
  trans-golgi network protein 2
  transmembrane protein 17
  transmembrane protein 216
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  VPS37C subunit of ESCRT-I
  zinc finger CCCH-type containing 10

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.