RAMP1, receptor activity modifying protein 1

RAMP1, receptor activity modifying protein 1

• The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

• Gene Synonyms (receptor activity-modifying protein 1, CRLR activity-modifying protein 1, calcitonin receptor-like receptor activity modifying protein 1, receptor (G protein-coupled) activity modifying protein 1, receptor (calcitonin) activity modifying protein 1,)
• NCBI Gene ID: 10267
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60894
  UNIPROT ID#>>E9PC20
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

receptor activity modifying protein 1 interacts with:

• membrane spanning 4-domains A13
  MUS81 structure-specific endonuclease subunit
  receptor activity modifying protein 1

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