TRIM22, tripartite motif containing 22

TRIM22, tripartite motif containing 22

• The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

• Gene Synonyms (GPSTAF50, RNF94, STAF50, E3 ubiquitin-protein ligase TRIM22, 50 kDa-stimulated trans-acting factor, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, staf-50, stimulated trans-acting factor (50 kDa), tripartite binding motif 22, tripartite motif protein TRIM22, tripartite motif-containing protein 22,)
• NCBI Gene ID: 10346
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IYM9
  UNIPROT ID#>>B4DQS5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tripartite motif containing 22 interacts with:

• capicua transcriptional repressor
  pleckstrin homology and FYVE domain containing 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  tripartite motif containing 22
  zinc finger ZZ-type containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.