BPNT1, 3'(2'), 5'-bisphosphate nucleotidase 1

BPNT1, 3'(2'), 5'-bisphosphate nucleotidase 1

• BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HEL20, PIP, 3'(2'),5'-bisphosphate nucleotidase 1, BPntase, PAP-inositol-1,4-phosphatase, bisphosphate 3'-nucleotidase 1, epididymis luminal protein 20, testicular tissue protein Li 29,)
• NCBI Gene ID: 10380
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95861
  UNIPROT ID#>>V9HWF9
  UNIPROT ID#>>B7Z9J7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

3'(2'), 5'-bisphosphate nucleotidase 1 interacts with:

• abhydrolase domain containing 18
  acyl-CoA dehydrogenase family member 10
  acyl-CoA synthetase family member 2
  apolipoprotein L2
  asparaginyl-tRNA synthetase 2, mitochondrial
  choline dehydrogenase
  dynein 2 intermediate chain 1
  fumarylacetoacetate hydrolase domain containing 1
  GDP-D-glucose phosphorylase 1
  GTP binding protein 10
  GTP dependent ribosome recycling factor mitochondrial 2
  leucine rich repeat kinase 2
  leucine rich repeats and calponin homology domain containing 2
  leucyl-tRNA synthetase 2, mitochondrial
  mediator of cell motility 1
  minichromosome maintenance 8 homologous recombination repair factor
  mitochondrial calcium uptake 2
  mitochondrial ribosome associated GTPase 1
  mitochondrial ribosome associated GTPase 2
  mitochondrial tRNA translation optimization 1
  NADH:ubiquinone oxidoreductase complex assembly factor 7
  NOP2/Sun RNA methyltransferase 4
  nudix hydrolase 19
  peptide deformylase, mitochondrial
  protein tyrosine phosphatase mitochondrial 1
  pyruvate dehydrogenase phosphatase regulatory subunit
  radical S-adenosyl methionine domain containing 1
  ribonuclease H2 subunit A
  RNA exonuclease 5
  seryl-tRNA synthetase 2, mitochondrial
  short chain dehydrogenase/reductase family 39U member 1
  TBC1 domain family member 9B
  transport and golgi organization 2 homolog
  tubulin beta 3 class III
  valyl-tRNA synthetase 2, mitochondrial

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.