MCM8, minichromosome maintenance 8 homologous recombination repair factor

MCM8, minichromosome maintenance 8 homologous recombination repair factor

• The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

• Gene Synonyms (DNA helicase MCM8, DNA replication licensing factor MCM8, MCM8 minichromosome maintenance deficient 8, REC homolog, minichromosome maintenance complex component 8, C20orf154, POF10, dJ967N21.5,)
• NCBI Gene ID: 84515
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UJA3
  UNIPROT ID#>>B4DN82
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

minichromosome maintenance 8 homologous recombination repair factor interacts with:

• IQ motif containing F1
  kelch like family member 40
  minichromosome maintenance 8 homologous recombination repair factor
  minichromosome maintenance 9 homologous recombination repair factor
  pregnancy specific beta-1-glycoprotein 8
  sorting nexin family member 21
  TSPY like 6
  tubulin beta class I

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.