MERTK, MER proto-oncogene, tyrosine kinase

MERTK, MER proto-oncogene, tyrosine kinase

• This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

• Gene Synonyms (MER, RP38, Tyro12, c-Eyk, c-mer, tyrosine-protein kinase Mer, MER receptor tyrosine kinase, STK kinase, c-mer proto-oncogene tyrosine kinase, proto-oncogene c-Mer, receptor tyrosine kinase MerTK,)
• NCBI Gene ID: 10461
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q12866
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MER proto-oncogene, tyrosine kinase interacts with:

• MER proto-oncogene, tyrosine kinase
  NEDD4 like E3 ubiquitin protein ligase
  TNFAIP3 interacting protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.