FBLN5, fibulin 5

FBLN5, fibulin 5

• The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]

• Gene Synonyms (ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, HNARMD, UP50, fibulin-5, developmental arteries and neural crest EGF-like protein, embryonic vascular EGF-like repeat-containing protein, testis tissue sperm-binding protein Li 75n, urine p50 protein,)
• NCBI Gene ID: 10516
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBX5
  UNIPROT ID#>>A0A024R6G3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

fibulin 5 interacts with:

• DnaJ heat shock protein family (Hsp40) member C10
  IQ motif containing N
  nuclear FMR1 interacting protein 2
  PAX interacting protein 1
  transketolase like 2
  ZFP41 zinc finger protein
  zinc finger protein 331
  zinc finger protein 408
  zinc finger protein 550

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.