POMT1, protein O-mannosyltransferase 1

POMT1, protein O-mannosyltransferase 1

• The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

• Gene Synonyms (LGMD2K, LGMDR11, MDDGA1, MDDGB1, MDDGC1, RT, protein O-mannosyl-transferase 1, dolichyl-phosphate-mannose--protein mannosyltransferase 1, testis tissue sperm-binding protein Li 57p, truncated O-mannosyl-transferase 1 variant SV3DEL,)
• NCBI Gene ID: 10585
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VKE0
  UNIPROT ID#>>Q9Y6A1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein O-mannosyltransferase 1 interacts with:

• 5-hydroxytryptamine receptor 3C
  alpha-1,4-N-acetylglucosaminyltransferase
  ATPase Na+/K+ transporting family member beta 4
  beta-1,4-glucuronyltransferase 1
  butyrophilin like 8
  CD244 molecule
  metallophosphoesterase 1
  negative regulator of reactive oxygen species
  neutral cholesterol ester hydrolase 1
  pleckstrin homology domain containing A4
  potassium two pore domain channel subfamily K member 16
  protein O-mannose kinase
  protein O-mannosyltransferase 2
  protocadherin alpha 4
  protocadherin beta 7
  raftlin family member 2
  spectrin repeat containing nuclear envelope family member 4
  tectonic family member 2
  transmembrane protein 92
  transmembrane serine protease 12
  uroplakin 1A
  von Willebrand factor C and EGF domains
  zinc activated ion channel

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.